Cancer

Download Yeast as a Tool in Cancer Research by Julie M. Bailis, Susan L. Forsburg (auth.), John L. Nitiss, PDF

By Julie M. Bailis, Susan L. Forsburg (auth.), John L. Nitiss, Joseph Heitman (eds.)

Leland H. Hartwell Director, Fred Hutchinson melanoma study middle, Nobel Laureate for medication, 2001 Yeast has proved to be the main beneficial single-celled organism for learning the basic features of cellphone biology. assets at the moment are to be had for yeast that drastically simplify and empower new investigations, just like the presence of traces with every one gene deleted, every one protein tagged and databases on protein–protein interactions, gene legislation, and subcellular protein position. a robust mixture of genetics, mobilephone biology, and biochemistry hired by way of hundreds of thousands of yeast researchers has unraveled the complexities of diverse mobile methods from mitosis to secretion or even exposed new insights into prion illnesses and the position of prions in basic biology. those insights have confirmed, many times, to predict the jobs of proteins and pathways in human cells. the gathering of articles during this quantity explores using yeast in pathway research and drug discovery. Yeast has, in fact, provided mankind’s so much ubiquitous drug for millions of years. in a single element, the function of yeast in drug discovery is far just like the position of yeast in different parts of biology. Yeast deals the ability of genetics and a repetoire of assets to be had in no different organism. utilizing yeast within the examine of drug goals and metabolism may also help to make a technological know-how of what has been principally an empirical task. A technological know-how of drug discovery could enable rigorous solutions to big questions.

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Murray, J. , M. Tavassoli, R. Al-Harithy, K. S. Sheldrick, A. R. Lehman, A. M. Carr, and F. Z. Watts. 1994. Structural and functional conservation of the human homologue of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage. Mol. Cell. Biol. 14:4878– 4888. 133. , C. Chen, and R. D. Kolodner. 2001. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature 411:1073–1076. 134. , A. Datta, and R.

W. Murray, and S. H. Friend. 1997. Integrating genetic approaches into the discovery of anticancer drugs. Science 278:1064–1068. 61. , D. Fisher, A. Woollard, and P. Nurse. 1994. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2 mitotic B cyclin complex. Cell 78:813–822. 62. , M. Madine, S. Dalton, and J. Gautier. 1996. Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex. Proc. Natl. Acad. Sci.

106. , C. Cotta-Ramusino, A. Pellicioli, G. Liberi, P. Plevani, M. Muzi-Falconi, C. S. Newlon, and M. Foiani. 2001. The DNA replication checkpoint response stabilizes stalled replication forks. Nature 412:557–561. 107. , and P. Nurse. 1999. The fission yeast origin recognition complex is constitutively associated with chromatin and is differently modified through the cell cycle. J. Cell Sci. 112:3703–3712. 108. , G. Blom van Assendelft, and S. E. Kearsey. 1996. Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and located in the nucleus throughout the cell cycle.

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