Critical Care

Download Core Topics in Neuroanaesthesia and Neurointensive Care by Basil F. Matta, David K. Menon, Martin Smith PDF

By Basil F. Matta, David K. Menon, Martin Smith

Middle subject matters in Neuroanesthesia and Neurointensive Care is an authoritative and functional scientific textual content that gives transparent diagnostic and administration tips for quite a lot of neuroanesthesia and neurocritical care difficulties. With assurance of each point of the self-discipline by way of notable international specialists, this could be the 1st e-book to which practitioners flip for simply obtainable and definitive suggestion. preliminary sections disguise correct anatomy, body structure and pharmacology, intraoperative and demanding care tracking and neuroimaging. those are by means of distinctive sections protecting all elements of neuroanesthesia and neurointensive care in either grownup and pediatric sufferers. the ultimate bankruptcy discusses moral and felony matters. every one bankruptcy offers a state-of-the artwork evaluation of scientific perform, together with consequence information while on hand. more advantageous all through with various medical photos and line drawings, this useful and available textual content is essential analyzing for trainee and advisor anesthetists and significant care experts.

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8). 5 minimum alveolar concentration (MAC). In another study, 1% halothane was shown to result in clinically significant elevations in ICP in patients with intracranial space-occupying lesions. Studies with enflurane and isoflurane suggest that these agents might produce smaller increases in CVR at equivalent doses. As enflurane may produce epileptogenic activity, its use in the context of neuroanaesthesia has decreased. Several studies compared the effects of isoflurane and halothane on CBF, with conflicting results.

L. Jr (1971). Effects of stimulation of cervical sympathetic nerves on cortical blood flow and vascular reactivity. Neurology 21, 297–302. Macfarlane, R. and Moskowitz, M. A. (1995). The innervation of pial blood vessels and their role in cerebrovascular regulation. , Brain Ischemia: Basic Concepts and Clinical Relevance. London: Springer Verlag, pp. 247–59. , Moskowitz, M. , Sakas, D. E. et al. (1991). The role of neuroeffector mechanisms in cerebral hyperperfusion syndromes. J Neurosurg 75, 845–55.

Suggested cellular mechanisms by which astrocytes regulate cerebral metabolism (and hence CBF) are the glycolytic utilization of glucose with lactate production and maintenance of potassium homeostasis. Astrocytic glucose utilization and lactate production appear to be, in large part, coupled by the astrocytic reuptake of glutamate released at excitatory synapses, and the lactate produced by astrocytic glycolysis serves as a substrate for neuronal oxidative metabolism (Fig. 5). The regulatory changes involved in flow–metabolism coupling that have a short latency (~1 s) are mediated either by metabolic or neurogenic pathways.

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