Cancer

Download Cancer and Autoimmunity (Autoanitbody Library) by Y. Shoenfeld (Editor), M.E. Gershwin (Editor) PDF

By Y. Shoenfeld (Editor), M.E. Gershwin (Editor)

Of the 2 disciplines in parallel improvement for 2 many years, tumor immunology and transplantation immunology, the latter has thrived and has ended in essentially the most serious discoveries in immunobiology. the previous maintains to thwart either scientists and clinicians alike. The objective of immunologists in modern-day examine is to boost an easy and potent potential to govern melanoma in vivo, in all probability encompassing a number of venues: picking a phenotypic marker and using both energetic or passive immunization; comprise using passive reagents sporting "warheads" to selectively wreck melanoma cells; or changing the fundamental means of mobile survival. this wonderful multidiscipline-authored quantity provides a subject matter which has now not been good defined ahead of. The papers contain either easy and medical technological know-how and variety from refined molecular biology to little greater than phenomenology (e.g. the elevated organization of melanoma in a few autoimmune illnesses and elevated presentation of autoimmune phenomena in malignant condition). This, even though, is state of the art. This number of subject matters can be of use not just to bench scientists, but in addition to clinicians who deal with sufferers. The e-book represents growth on the leading edge of this self-discipline, and issues find out how to extra advancements within the "black field" of immunology.

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B and T cells from SLE patients were also found to express the bcl-2 oncogene which is associated with prolonged survival of lymphocytes and protection from apoptosis. This oncogene is highly associated with human follicular lymphoma [77].

Crofts MA, Sharp JC, Joyner MV. Rheumatoid arthritis and hairy cell leukemia. Lancet 1979;28(2):203204. Lipton JH, Messner HA. Chronic myeloid leukemia in a woman with Still's disease treated with 198 Au synoviorthesis. J Rheumatol 1991;18:734-735. Kapadia SB, Kaplan SS. Acute melogenous leukemia following immunosuppressive therapy for rheumatoid arthritis. Am J Clin Pathol 1978;70:301-302. Kauppi MJ, Savolainen HA, Anttila VJ, Isomaki HA. Increased risk of leukemia in patients with juvenile chronic arthritis treated with chlorambucil.

These include (a) the use of cytotoxic drugs which may act through induction of chromosomal abnormalities, direct oncogenic effect by facilitating the development of latent and chronic infection with EBV and other viruses, and (b) expansion and malignant transformation of the lymphocytic clones as a result of all of the immunogenetic mechanisms involved in the pathogenesis of RA. REFERENCES 1. Harris ED. Clinical features of rheumatoid arthritis. , Textbook of Rheumatology, 5th edn. Philadelphia: WB Saunders 1997:895-922.

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