Action

Download Calcium in Drug Action by L. Rosenberger, D. J. Triggle (auth.), George B. Weiss PDF

By L. Rosenberger, D. J. Triggle (auth.), George B. Weiss (eds.)

Anyone surveying physiological and pharmacological journals can without difficulty see that the organic activities of calcium ion are of more and more common present curiosity. The scope of investi­ gated activities and reactions during which a task for calcium ion is of a few significance is so a number of as to express the impact that calcium ion is in every single place and interacts with every little thing. This being so, the problem in modern learn is to target research of these activities of calcium ion which, in a few demeanour, effect both major physiological parameters or the style during which pharmacological brokers act. This multi-authored e-book originated from a extra restricted Symposium on "Importance of Calcium as a main Locus of Drug motion" co-chaired alone and Dr. Frank R. Goodman on the April, 1977 FASEB assembly in Chicago. This Symposium used to be equipped according to a perceived want for elevated conversation between 2 employees in numerous parts of Ca +-related study. within the seasoned­ cess of choosing the utmost of six components for presentation in the layout supplied, it quickly turned obvious that this is able to lead to just a restricted sampling of present study efforts. growth of the variety of parts to 14 inside of a ebook structure seemed to be the main logical mechanism to supply a extra coherent inter­ disciplinary method of attention of assorted points of the two roles of Ca + in drug motion. this isn't to suggest that each one rele­ 2 vant Ca +-related parts are surveyed inside this volume.

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1974, Effect of verapamil on the normal action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibres, Circ. Res. 34: 204. D'Arrigo, J. , 1973, Possible screening of surface charges on crayfish axons by polyvalent metal ions, J. Physiol. (London) 231: 117. Desmedt, J. , 1976, The effect of A23l87 ionophore on calcium movements and contraction processes in single barnacle muscle fibres, J. Physiol. (London) 257: 87. Diamond, J. , and Wright, E. , 1969, Biological Membranes: the physical basis of ion and nonelectrolyte selectivity, Annu.

And Marshall, J. , 1975, Action of 0-600 on spontaneous and electrically stimulated activity of the parturient rat uterus, Naunyn-Schmied. Arch. Pharmacol. 290: 21. , 1973, Divalent cations as charge carriers in excitable membranes, Progr. Biophys. Mol. Biol. 26: 1. , 1974, Localization of beta-adrenergic receptors and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle, J. Physiol. (London) 264: 17. , 1977, The regulation of the calcium conductance of cardiac muscle by adrenaline, J.

10 8 '0 6 • ...... ,e. t heart ~ e '1-.. · . . . . ~ }" 40 ~ Froq -..... "........ G-piq .... SMA 4 o I j 10 20 30 40 50 60 70 80 I I 90 100 I 110 120 Time (min) Figure 1. Rate of tension decline of intra-arterially perfused guinea pig interventricular septa and semimembranosus accessorius (SMW) muscles and frog gastrocnemius (FC) muscles during calciumfree perfusion. 100 ~M La 3+ added 70 zero Ca 2 + solutions to maintain resting membrane potential and excitability. J. E. ) shown in brackets.

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