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By Mehmet Gunduz; Esra Gunduz

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We try to bring some response elements in this chapter, emphasising the in vitro models the most useful and the most frequently used. But we also show that no model is perfect and sufficient by itself, and that pure in vitro models also need assistance of in vivo ones. 22 Breast Cancer – Focusing Tumor Microenvironment, Stem Cells and Metastasis 2. 1 The different cell lines and their main properties Significant amounts of data on breast cancer have been collected over the past 40 years, thanks to the use of established cell lines.

1983). [In vitro cultivation of vital tissue slices: a new variation of organ culture technics]. Biomed Biochim Acta, Vol. 7-8: 907-916. Nizamutdinova, I. , Lee, G. , Lee, J. , Cho, M. , Son, K. , Jeon, S. , Kang, S. , Kim, Y. , Lee, J. , Seo, H. , Chang, K. C. and Kim, H. J. (2008). Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules. Carcinogenesis, Vol. 10: 1885-1892. Ozzello, L. and Sordat, M. (1980). Behavior of tumors produced by transplantation of human mammary cell lines in athymic nude mice.

Liscovitch, M. and Ravid, D. (2007). A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian carcinoma cells. Cancer Lett, Vol. 1-2: 350-352. , Ahmed, S. and Matthews, J. (2010). Estrogen receptordependent regulation of CYP2B6 in human breast cancer cells. Biochim Biophys Acta, Vol. 5-6: 469-479. Macpherson, L. and Matthews, J. (2010). Inhibition of aryl hydrocarbon receptor-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor alpha expression in human breast cancer cells.

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