By S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, Prof. Dr. med. Wolfgang Wilmanns (eds.)
Physicians, biologists and physicists current their fresh paintings within the box of hyperthermia with reference to either its program and its mix with radiation and chemotherapy. present technical chances, scientific administration and significant features of its use for superficial and deep-seated tumors are mentioned. the most subject matters mentioned are: adjustments of metabolism and microcirculation below warmth stipulations, the organic interplay of warmth with X-rays and a number of other chemotherapeutic brokers, and the latest scientific information from diverse associations at the mixed program within the remedy of cancer.
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Extra resources for Application of Hyperthermia in the Treatment of Cancer
Human 0 • i qO i q1 i q2 • Sq cell Sa i q3 qq qS temperature ( °C ) Fig. 5. Time-temperature plot of the available data on reduction of the microcirculation. References for the various tumour types indicated in the diagram are as follows: Ascites carcinoma (Scheid 1961); Carcinoma NT and MT (Stewart and Begg (1983); DS carcinoma (von Ardenne and KrUger 1980; Vaupel et al. 1980); Ependymoblastoma (Sutton 1976); Hepatoma (Karino et al. 1984); Human tumours (various), whole-body hyperthermia (Karino et al.
Cool skin at 34 C, the circulation in the tumour may appear to be higher than in the normal tissue. However, under conditions of heating this relationship may change considerably. This will be discussed below. Figure 1 gives an idea of this relationship. The values used in this figure are derived from many different sources, including textbooks. The normal tissues are listed in increasing order of blood flow. In the lower part some tumour values are shown with the values of the tissue of origin, while in the upper part some published values on a variety of tumours is depicted.
The plasma acetate levels in six of these patients showed a decrease of the plasma acetate level from the first to the third cycle. These patients responded to the therapy. One patient did not show an increased level at the initiation of treatment and did not respond to the therapy (Fig. 2). 3. In six patients receiving chemotherapy without hyperthermia, no changes in plasma acetate levels were observed when blood samples were examined at the same time intervals as in the hyperthermia group. Changes of Plasma Acetate Levels in Whole-Body Hyperthennia 29 Table i.