Download Apoptosis, Senescence, and Cancer by Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn PDF

By Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn E. Holt, Steven Grant (eds.)

Apoptosis, Senescence and melanoma presents perception into tested practices and examine into apoptosis and senescence through completely interpreting novel and rising innovations and examine within the fields of phone dying pathways, senescence progress arrest, medicines and resistance, DNA harm reaction, and different subject matters which nonetheless carry mysteries for researchers.

The quantity is split into six effortless to persist with sections. the 1st is Apoptosis and replacement Modes of phone demise, by means of chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The 3rd half covers DNA harm reaction, Signaling Pathways and Tumorigenesis, whereas the fourth delves into Resistance and Sensitization. The booklet concludes with confirmed melanoma remedies and a piece which seems towards the long run with fresh and constructing melanoma Therapies.

In overall, this quantity presents uncomplicated scientists and clinicians with a deeper and extra whole figuring out of the mobile responses of malignancies that could ascertain the effectiveness of therapy, either within the preliminary phases of the sickness in addition to in disorder recurrence.

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Extra resources for Apoptosis, Senescence, and Cancer

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J Biol Chem 2000; 275:23065–73. 42. Martin SJ, Reutelingsperger CP, McGahon AJ, et al. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182(5):1545–56. 43. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002; 417:182–7. 44. Hanayama R, Tanaka M, Miyasaka K, et al.

Villunger A, Michalak EM, Coultas L, et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003; 302(5647):1036–8. 107. Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53–dependent and independent apoptotic pathways. Cancer Cell 2003; 4(4):321–8. 108. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell 1994; 79(2): 189–92. 109. Perez D, White E. TNF-alpha signals apoptosis through a Bid-dependent conformational change in Bax that is inhibited by E1B 19K.

Fulda S, Meyer E, Friesen C, Susin SA, Kroemer G, Debatin K-M. Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene 2001; 20:1063–75. 214. Houghton JA, Harwood FG, Gibson AA, Tillman DM. The Fas signaling pathway is functional in colon carcinoma cells and induces apoptosis. Clin Cancer Res 1997; 3:2205–9. 215. Ito Y, Pandey P, Place A, et al. The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism.

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