Critical Care

Download Antifungal Therapy by Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, PDF

By Mahmoud Ghannoum, Mahmoud A. Ghannoum, John R. Perfect MD, John R. Perfect

A concise one-stop-practical reference for some of the physicians facing fungal infections, Antifungal treatment appeals to infectious sickness physicians, transplant surgeons, dermatologists, and intensivists, in addition to simple scientists and pharmaceutical corporation researchers attracted to the nation of antifungal remedy. This booklet presents a finished, updated review of the pertinent matters touching on antifungal therapy. Divided into 4 interrelated sections for a cohesive dialogue covers:

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Example text

Paracoccidioides infection has also been reported in patients with HIV (310,311,316,317). Penicillium marneffei Penicillium marneffei is the only dimorphic fungus in the genus Penicillium. Other Penicillium species are hyaline, saprophytic molds which rarely cause infection and are known to contaminate plates in microbiology labs, whereas Penicillium marneffei infections are frequently reported in HIV-infected individuals. This fungus is geographically restricted to Southeast Asia and China though reports of infection have come from Europe, Australia, and the United States in HIV-infected and other immunosuppressed travelers (4–6,56,244,318).

Characteristic “bull’s eye” lesions (target-like abscesses) may be seen with ultrasound, MRI, or CT examination of the liver and spleen, but these lesions are not generally detectable radiographically until neutrophil recovery has occurred. Although not common, when present, a characteristic macronodular rash may be isolated (extremities, abdomen) or may cover the entire body and is frequently confused with a drug reaction (369). In a review of 53 documented systemic candidiasis cases, 36% (19/55) had skin lesions.

Marr KA, Carter RA, Boeckh M, et al. Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 2002; 100(13):4358–4366. 35. Wald A, Leisenring W, van Burik JA, et al. Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation. J Infect Dis 1997; 175(6):1459–1466. 36. Kontoyiannis DP, Lionakis MS, Lewis RE, et al. Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: A case-control observational study of 27 recent cases.

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