By GEORGE F. & GEORGE KLIEN (eds.) VANDE WOUDE
Meant for easy and scientific researchers, immunologists, virologists and molecular biologists, this ebook is a part of a chain which provides severe overviews on chosen points of either melanoma examine and the fundamental underlying sciences.
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Similarly to the V rearrangement situation, the c-my gene, on translocation into the immunoglobulin domain, could come under the influence of the cis-acting immunoglobulin LAR. This would result in maintenance of an active c-myc chromatin configuration and transcriptional activation in a cell type in which c-my may normally be repressed at the levels of chromatin structure and gene expression. One of the consequences of translocation, besides an increased transcription initiation from normal or cryptic promoters, may be the shift in promoter use that is characteristic of BL c-my expression.