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By H. Arnouk

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Gov/show/NCT01094496 NLM Identifier Number : NCT01094496. F. (1992). Management of stage T1 superficial bladder cancer with intravesical bacillus Calmette-Guerin therapy. The Journal of Urology, Vol. 148, No. 3, (September 1992), pp. P. (2006). Vaccination of hormonerefractory prostate cancer patients with peptide cocktail-loaded dendritic cells: results of a phase I clinical trial. Prostate, Vol. 66, No. 8, (June 2006), pp. 811-821. , & Stenzl A. (2009). Novel multipeptide vaccination in HLA-A2+ hormone sensitive patients with biochemical relapse of prostate cancer.

Journal of Clinical Oncology, Vol. 27, No. 25, (September 2009), pp. , & Miller J. (2002). An autologous large multivalent immunogen (LMI) vaccine for the treatment of metastatic melanoma and renal cell carcinoma, Proceedings of American Society of Clinical Oncology, 2002;21:20a Oxford BioMedica & MedSource. A Randomized Phase II Study to Assess the Activity of TroVax® (MVA-5T4) Plus Docetaxel Versus Docetaxel Alone in Subjects With Progressive Hormone Refractory Prostate Cancer. gov [Internet].

Heat shock proteins have two properties of interest. First, they chaperone peptides, and second, they interact with antigen presenting cells in such a manner that leads to the presentation of heat shock protein-chaperoned peptides by the major histocompatibility complex class I molecules of antigen presenting cells. This has brought researchers to the following conclusions: (1) heat shock proteins chaperoning peptides is an essential part of the mechanism through which major histocompatibility complex class I molecules are charged, (2) heat shock protein-peptide complexes, rather than intact antigens, are responsible for antigens transfer during cross-presentation or cross-priming, and (3) heat shock protein-peptide complexes provide a distinct antigenic fingerprint for specific cancer tissues, which can be utilized in the development of cancer therapies.

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